購(gòu)物車(chē)
幫助
021-54845833/15800441009
中文名稱： CASR 抗原（重組蛋白）
英文名稱：CASR Antigen (Recombinant Protein)
別 名：calcium sensing receptor; CAR; FHH; FIH; HHC; EIG8; HHC1; NSHPT; PCAR1; GPRC2A; HYPOC1
儲(chǔ) 存：冷凍（-20℃）
相關(guān)類(lèi)別：抗原
技術(shù)規(guī)格
|
Full name: |
calcium sensing receptor |
|
Synonyms: |
CAR; FHH; FIH; HHC; EIG8; HHC1; NSHPT; PCAR1; GPRC2A; HYPOC1 |
|
Swissprot: |
P41180 |
|
Gene Accession: |
BC112236 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. |
