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中文名稱： 兔抗PTEN(Phospho-Ser370) 多克隆抗體
英文名稱： Anti-PTEN(Phospho-Ser370) rabbit polyclonal antibody
別 名： This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded t
相關(guān)類別： 一抗
儲(chǔ) 存： 冷凍（-20℃） 避光
宿 主： Rabbit
抗 原： PTEN(Phospho-Ser370)
反應(yīng)種屬： Human Mouse Rat
標(biāo) 記 物： Unconjugate
克隆類型： Unconjugate
技術(shù)規(guī)格
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Background: |
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. |
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Applications: |
WB, IHC, IF |
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Name of antibody: |
PTEN(Phospho-Ser370) |
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Immunogen: |
Peptide sequence around phosphorylation site of serine 370(D-V-S(p)-D-N) derived from Human PTEN. |
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Full name: |
phosphatase and tensin homolog |
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Synonyms： |
0 |
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SwissProt: |
P60484 |
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IHC positive control: |
Human breast carcinoma tissue |
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IHC Recommend dilution: |
50-100 |
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WB Predicted band size: |
47 kDa |
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WB Positive control: |
Hela cells lysate |
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WB Recommended dilution: |
500-1000 |
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IF positive control: |
MCF7 cells |
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IF Recommend dilution: |
100-200 |
