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021-54845833/15800441009
中文名稱(chēng)： 兔抗NCOA1多克隆抗體
英文名稱(chēng)： Anti-NCOA1 rabbit polyclonal antibody
別 名： NCOA1; F-SRC-1; KAT13A; MGC129719; MGC129720; NCoA-1; RIP160; SRC-1; SRC1; bHLHe42; bHLHe74
相關(guān)類(lèi)別： 一抗
儲(chǔ) 存： 冷凍（-20℃） 避光
宿 主： Rabbit
抗 原： NCOA1
反應(yīng)種屬： Human, Mouse, Rat
標(biāo) 記 物： Unconjugate
克隆類(lèi)型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
There are three members of the steroid receptor co-activator (SRC) family of proteins: SRC-1 (NCoA-1), SRC-2 (TIF2/GRIP1/NCoA-2), and SRC-3 (ACTR/pCIP/RAC3/TRAM-1/AIB1). All SRC family members share significant structural homology and function to stimulate transcription mediated by nuclear hormone receptors and other transcriptional activators such as Stat3, NF-κB, E2F1, and p53). Two SRC proteins, SRC-1 and SRC-3, function as histone acetyltransferases. In addition, all three family members can recruit other histone acetyltransferases (CBP/p300, PCAF) and histone methyltransferases (PRMT1, CARM1) to target promoters and cooperate to enhance expression of many genes. The SRC proteins play important roles in multiple physiological processes including cell proliferation, cell survival, somatic cell growth, mammary gland development, female reproductive function, and vasoprotection). SRC-1 and SRC-3 are conduits for kinase-mediated growth factor signaling to the estrogen receptor and other transcriptional activators. Seven SRC-1 phosphorylation sites and six SRC-3 phosphorylation sites have been identified, which are induced by steroids, cytokines, and growth factors and involve multiple kinase signaling pathways). Research has shown that all three SRC family members are associated with increased activity of nuclear receptors in breast, prostate, and ovarian carcinomas. According to the literature, SRC-3 is frequently amplified or overexpressed in a number of cancers, and SRC-1/PAX3 and SRC-2/MYST3 translocations are found associated with rhabdomyosarcoma and acute myeloid leukemia, respectively. |
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Applications: |
WB |
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Name of antibody: |
NCOA1 |
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Immunogen: |
Fusion protein of human NCOA1 |
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Full name: |
nuclear receptor coactivator 1 |
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Synonyms： |
NCOA1; F-SRC-1; KAT13A; MGC129719; MGC129720; NCoA-1; RIP160; SRC-1; SRC1; bHLHe42; bHLHe74 |
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SwissProt: |
Q15788 |
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WB Predicted band size: |
157 kDa |
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WB Positive control: |
Testis tissue |
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WB Recommended dilution: |
500-2000 |
