Name: HLA-DRB4 抗原（重組蛋白）
Brand: 通蔚生物

中文名稱：HLA-DRB4 抗原（重組蛋白）

英文名稱： HLA-DRB4 Antigen (Recombinant Protein)

別名： major histocompatibility complex, class II, DR beta 4; DR4; DRB4; HLA-DR4B

儲(chǔ) 存： 冷凍（-20℃）

相關(guān)類別： 抗原

概述：

Fusion protein corresponding to a region derived from 30-266 amino acids of human HLA-DRB4

技術(shù)規(guī)格：

Full name:	major histocompatibility complex, class II, DR beta 4
Synonyms:	DR4; DRB4; HLA-DR4B
Swissprot:	P13762
Gene Accession:	BC005312
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.

ELISA試劑盒

PCR試劑盒