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中文名稱： 兔抗MAP2K2多克隆抗體
英文名稱： Anti-MAP2K2 rabbit polyclonal antibody
別 名： MEK2, MKK2, MAPKK2, PRKMK2
相關(guān)類別： 一抗
儲(chǔ) 存： 冷凍（-20℃）
宿 主： Rabbit
抗 原： MAP2K2
反應(yīng)種屬： Human, Mouse, Rat
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
MAP2K2 |
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Immunogen: |
Synthetic peptide of human MAP2K2 |
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Full name: |
mitogen-activated protein kinase kinase 2 |
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Synonyms: |
MEK2, MKK2, MAPKK2, PRKMK2 |
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SwissProt: |
P36507 |
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IHC positive control: |
Human gastric cancer and human ovarian cancer |
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IHC Recommend dilution: |
100-300 |
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WB Predicted band size: |
44 kDa |
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WB Positive control: |
Hela, NIH/3T3 and Jurkat cells |
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WB Recommended dilution: |
1000-5000 |
